Translational Laboratories Functional Tissue Imaging Unit (Alberta Health Services) – Angela Chan
Angela Chan is the Acting Functional Tissue Imaging Unit Operation Lead in the Translational Laboratories of the Tom Baker Cancer Centre. As the unit lead, she collaborates with Dr. Bebb to identify and quantify biomarkers in tissue samples from patients in the Glans-Look Lung Cancer Research Program. This is achieved using fluorescent immunohistochemistry, which involves the highly sensitive detection of specific proteins using antibodies and fluorescent labels and quantification using digital pathology platforms. The expression and localization of these proteins can provide useful information that can guide the diagnosis and treatment of lung cancer and improvement of patient care.
Angela’s research interests include development of quality controls for immunohistochemistry, and the use of these controls to standardize quantitative immunohistochemistry in clinical laboratories. Recently, she started to explore the area of multiplex IHC and artificial intelligence for digital images analysis. She also have a strong molecular biology background where she works with molecular scientist in the Translational Laboratories doing Next Generation Sequencing for mutational analysis, copy number analysis and gene expression Analysis. She received her MSc in Department of Biochemistry and Molecular Biology in Faculty of Medicine at the University of Calgary, where she worked on signaling pathways that influence the survival and migration of cancer cells. She had industry experience through working in a biotechnology company and clinical diagnostic experience through working in Genetic Laboratories Services in Alberta Health Services as a licensed MLT (via substantial equivalency) before assuming her research position at the Translational Labs in 2009.